Here is the comprehensive article about the salary for a Registered Nurse in South Carolina.
Considering a career as a Registered Nurse (RN) in the Palmetto State? You're looking at a profession that is not only personally rewarding but also offers significant job security and a competitive salary. A career in nursing in South Carolina provides a stable foundation with ample opportunity for growth.
On average, a Registered Nurse in South Carolina can expect to earn an annual salary of approximately $82,000. However, this figure is just the starting point. Your actual earnings can vary significantly based on your experience, location, education, and specialization. This guide will break down everything you need to know about your potential earnings as an RN in South Carolina.
What Does a Registered Nurse Do?

Registered Nurses are the backbone of the healthcare system. They provide and coordinate patient care, educate patients and the public about various health conditions, and offer emotional support to patients and their families. Their responsibilities are diverse and critical, including:
- Assessing patient conditions and recording medical histories and symptoms.
- Administering medications and treatments.
- Collaborating with doctors and other healthcare professionals.
- Operating and monitoring medical equipment.
- Performing diagnostic tests and analyzing the results.
- Teaching patients and their families how to manage illnesses or injuries.
From the bustling trauma centers in Charleston to community health clinics in the Upstate, RNs are essential in every healthcare setting across South Carolina.
Average Registered Nurse Salary in South Carolina

When analyzing salary data, it's important to look at averages and ranges to get a complete picture. The most reliable data comes from government sources and reputable salary aggregators.
According to the U.S. Bureau of Labor Statistics (BLS) Occupational Employment and Wage Statistics report from May 2023, the most recent data available:
- Average Annual Salary: $81,990
- Average Hourly Wage: $39.42
- Median Annual Salary: $79,530 (This means half of all RNs in SC earn more than this, and half earn less).
To understand the full spectrum of earning potential, the BLS provides a percentile range:
- Top 10% of Earners: Over $103,110
- 75th Percentile: $87,030
- 25th Percentile: $74,800
- Bottom 10% of Earners (typically entry-level): Under $62,090
Other major salary aggregators provide similar estimates. For instance, Salary.com reports a median salary of $79,165 for a staff RN in South Carolina as of late 2024, while Glassdoor estimates an average total pay of $83,863 per year. These slight variations are due to different data sources (employer-reported vs. user-submitted), but they all point to a strong, competitive salary range.
Key Factors That Influence an RN's Salary

Your base salary is influenced by several key factors. Understanding these can help you maximize your earning potential throughout your nursing career in South Carolina.
### Level of Education
While you can become a licensed RN with an Associate Degree in Nursing (ADN), obtaining a Bachelor of Science in Nursing (BSN) is a powerful career move. Many major hospital systems and Magnet-designated facilities in South Carolina prefer or require a BSN. This preference often translates to a higher starting salary and opens doors to leadership, research, and specialized roles that come with increased compensation. Advancing further to a Master of Science in Nursing (MSN) allows you to become an Advanced Practice Registered Nurse (APRN), such as a Nurse Practitioner or Nurse Anesthetist, which command significantly higher salaries.
### Years of Experience
Experience is one of the most significant drivers of salary growth. As you gain clinical skills, confidence, and specialized knowledge, your value to employers increases.
- Entry-Level (0-2 years): New graduates in South Carolina can expect to start in the $62,000 to $74,000 range, depending on the facility and location.
- Mid-Career (5-9 years): With solid experience, an RN can expect to earn a salary closer to the state median and average, typically from $78,000 to $85,000.
- Experienced (10+ years): Senior RNs with a decade or more of experience, especially those in charge nurse or specialized roles, can command salaries well into the $90,000s and above $100,000.
### Geographic Location
Where you work in South Carolina matters. Salaries often reflect the cost of living and the demand for nurses in a specific metropolitan or rural area. According to BLS May 2023 data, here's how average annual RN salaries compare across the state:
- Hilton Head Island-Bluffton: $88,270
- Charleston-North Charleston: $85,020
- Myrtle Beach-Conway-North Myrtle Beach: $80,480
- Columbia: $80,070
- Greenville-Anderson: $79,890
- Upper Savannah SC Nonmetropolitan Area: $77,590
Coastal and resort areas like Hilton Head and Charleston tend to offer higher compensation, while salaries in the Midlands and Upstate are closer to the state average.
### Company Type / Work Setting
The type of facility where you work plays a crucial role in your salary. General medical and surgical hospitals are the largest employers of RNs and typically offer competitive wages and benefits packages. However, other settings can also be lucrative.
- Hospitals (State, Local, and Private): This is the most common and often one of the highest-paying settings for RNs.
- Outpatient Care Centers: These facilities may offer more regular hours and can provide competitive salaries, especially for specialized procedural roles.
- Home Health Care Services: This sector is growing rapidly and often offers pay-per-visit models that can be very profitable for efficient and organized nurses.
- Physicians' Offices: While salaries may be slightly lower than in acute care hospitals, these roles often provide a better work-life balance with traditional business hours.
### Area of Specialization
After gaining general experience, specializing in a high-demand, high-acuity area can significantly boost your income. Certifications in these specialties prove your expertise and make you a more valuable asset. High-paying RN specializations include:
- Intensive Care Unit (ICU)
- Operating Room (OR) / Perioperative Nursing
- Emergency Room (ER)
- Cardiac Catheterization Lab
- Labor and Delivery
Nurses in these fields often earn a "specialty differential" or a higher base pay due to the complexity and stress of the role.
Job Outlook for Registered Nurses in South Carolina

The future for Registered Nurses in South Carolina is exceptionally bright. The U.S. Bureau of Labor Statistics projects a national job growth of 6% for RNs from 2022 to 2032, which is faster than the average for all occupations.
The outlook in South Carolina is even stronger. According to Projections Central, which provides state-level data, the demand for Registered Nurses in South Carolina is expected to grow by 10.5% between 2022 and 2032. This translates to an estimated 3,920 average annual job openings due to a combination of new job creation and the need to replace retiring nurses. This high demand ensures strong job security and upward pressure on wages for the foreseeable future.
Conclusion

A career as a Registered Nurse in South Carolina is a pathway to a stable, fulfilling, and financially rewarding profession. With an average salary hovering around $82,000 and a robust job market, the opportunities are abundant.
Your earning potential is not static; it's something you can actively influence. By pursuing a BSN or higher, gaining valuable experience, choosing a strategic location, and developing a high-demand specialty, you can significantly increase your salary and advance your career. For anyone considering entering the healthcare field, becoming an RN in the Palmetto State is an excellent choice with a promising future.