Pursuing a Master of Science in Nursing (MSN) is one of the most significant steps a registered nurse can take to advance their career. It's a gateway to leadership roles, greater clinical autonomy, and, notably, a substantial increase in earning potential. If you're considering this advanced degree, you're likely asking a critical question: what salary can I expect?
While the answer varies, it's safe to say the return on investment is strong. Nurses with an MSN degree, particularly those in advanced practice roles, frequently earn six-figure salaries. It's not uncommon for top earners in specialized fields to command salaries well over $200,000 per year.
This guide will break down the salary landscape for MSN-prepared nurses, exploring the key factors that influence your income and the outstanding job outlook for this rewarding profession.
What Do Nurses with a Master's Degree Do?

An MSN degree qualifies you for roles that expand beyond traditional bedside nursing. These advanced positions often involve diagnosing illnesses, prescribing medication, leading healthcare teams, and managing patient care with a higher degree of independence.
MSN-prepared nurses typically fall into two main categories:
1. Advanced Practice Registered Nurses (APRNs): This is a protected title for nurses with advanced education and clinical training. The four main APRN roles are:
- Nurse Practitioner (NP): Provides primary, acute, and specialty care across the lifespan.
- Certified Registered Nurse Anesthetist (CRNA): Provides anesthesia and related care before, during, and after medical procedures.
- Certified Nurse-Midwife (CNM): Provides gynecological and maternity care.
- Clinical Nurse Specialist (CNS): Works within a specific specialty (e.g., oncology, pediatrics) to improve patient outcomes and nursing care.
2. Non-Clinical Roles: An MSN also opens doors to critical leadership and administrative positions, such as:
- Nurse Administrator / Healthcare Manager: Oversees nursing staff, manages budgets, and directs operations within a healthcare facility.
- Nurse Educator: Teaches in academic or clinical settings, training the next generation of nurses.
- Informatics Nurse Specialist: Manages and analyzes health information systems to improve patient care.
Average Master's in Nursing Salary

Because an MSN leads to a variety of different jobs, salary data is typically categorized by role rather than the degree itself. The U.S. Bureau of Labor Statistics (BLS) is the gold standard for this data.
According to the BLS Occupational Outlook Handbook, the median annual salary for Nurse Anesthetists, Nurse Midwives, and Nurse Practitioners was $128,490 as of May 2023. This figure represents the midpoint—half of the professionals in these roles earned more, and half earned less.
Salary aggregators provide a more granular look at the typical range:
- Salary.com reports that the average Nurse Practitioner (NP) salary in the United States is around $124,631, with a common range falling between $115,694 and $135,318.
- Payscale notes that the average salary for a professional holding an MSN degree is approximately $105,000, but this average includes lower-paying non-clinical roles like Nurse Educator alongside high-earning APRNs.
For those in leadership, the BLS reports a median annual salary of $110,680 for Medical and Health Services Managers, a category that includes Nurse Administrators.
Key Factors That Influence Salary

Your specific salary will depend on a combination of critical factors. Understanding these variables will help you maximize your earning potential throughout your career.
Area of Specialization
This is arguably the most significant factor impacting your salary. Among APRNs, some specializations command much higher pay due to the complexity of care, level of responsibility, and market demand.
- Certified Registered Nurse Anesthetist (CRNA): CRNAs are consistently the highest-paid nursing professionals. The BLS includes them in the general APRN category, but specialized data from Salary.com shows an average CRNA salary of $214,571 per year.
- Psychiatric Mental Health Nurse Practitioner (PMHNP): With a national shortage of mental health providers, PMHNPs are in extremely high demand, which drives up salaries. They often earn more than generalist NPs, with salaries frequently ranging from $130,000 to $150,000+.
- Family Nurse Practitioner (FNP): As one of the most common specializations, FNP salaries are generally close to the national average for NPs, typically $115,000 to $130,000.
- Nurse Educator: While vital to the profession, academic roles typically pay less than clinical positions. According to the BLS, the median salary for postsecondary nursing instructors was $80,780 in May 2023.
Geographic Location
Where you work matters. Salaries for MSN-prepared nurses vary significantly by state and even by metropolitan area, largely due to demand and cost of living.
According to the BLS (May 2023 data for NPs, CRNAs, and CNMs), the top-paying states are:
1. California: $164,090
2. New Jersey: $151,880
3. Massachusetts: $148,460
4. Oregon: $147,330
5. Washington: $146,090
It's important to balance a high salary against the local cost of living. A slightly lower salary in a state with more affordable housing and taxes can result in greater disposable income.
Years of Experience
As with any profession, experience is directly correlated with pay. As you accumulate skills, confidence, and a track record of positive patient outcomes, your value to employers increases.
- Entry-Level (0-2 years): New graduate NPs can expect to start at the lower end of the salary range, typically between $95,000 and $110,000.
- Mid-Career (5-10 years): With solid experience, you can expect to earn closer to or above the national median, in the $120,000 to $140,000 range.
- Senior/Experienced (10+ years): Highly experienced APRNs, especially those in high-demand specialties or leadership positions, can command salaries well over $150,000.
Work Setting
The type of facility you work in also plays a role. The BLS reports that work settings can impact APRN earnings:
- Outpatient Care Centers: Often the highest-paying setting, with a median salary of $139,880.
- Hospitals (State, Local, and Private): A very common employer, with a median salary of $134,810.
- Offices of Physicians: Median salary of $125,560.
- Educational Services: This setting, which includes university-affiliated hospitals, has a median salary of $116,910.
Level of Education
While this article focuses on the MSN, it's worth noting the terminal degree in nursing practice: the Doctor of Nursing Practice (DNP). While the MSN is the standard for entering advanced practice, a DNP can provide an additional salary boost, particularly for those seeking executive leadership, research, or academic faculty positions. Many organizations offer a salary differential for DNP-prepared nurses.
Job Outlook

The future for MSN-prepared nurses is exceptionally bright. The demand for advanced practice nurses is projected to grow dramatically in the coming years.
The BLS projects that employment for Nurse Anesthetists, Nurse Midwives, and Nurse Practitioners will grow by a staggering 38% between 2022 and 2032. This is much faster than the average for all occupations.
This explosive growth is driven by several factors:
- An aging population requiring more healthcare services.
- A greater focus on preventive care.
- Physician shortages, particularly in primary care and rural areas, where NPs and other APRNs are filling the gap.
Conclusion: A Worthwhile Investment in Your Future

Earning a Master of Science in Nursing is a significant commitment of time and resources, but the data clearly shows it is a sound financial investment that leads to a dynamic and rewarding career.
Key Takeaways:
- High Earning Potential: An MSN is your ticket to a six-figure salary, with top earners exceeding $200,000.
- Specialization is Key: Your chosen specialty, especially high-demand fields like anesthesiology (CRNA) and psychiatric mental health (PMHNP), is the biggest driver of your salary.
- Geography Matters: Your income can vary by tens of thousands of dollars depending on the state where you practice.
- Exceptional Job Security: With a projected growth rate of 38%, the demand for your skills will be extremely high for the foreseeable future.
Beyond the impressive salary and job security, a master's degree in nursing empowers you to function at the top of your license, providing a higher level of care, leading healthcare initiatives, and making a profound difference in the lives of your patients and your community.